Why do you need two doses of vaccination for COVID-19?

Vaccination is the safest approach to protect yourself against the coronavirus, and most COVID-19 vaccines require two doses to provide the best protection. For the optimum immunity, both Pfizer and AstraZeneca recommend two doses. It’s critical that you acquire the same COVID-19 immunization. This is because clinical trials have shown that it is effective, and that is what the various health authorities have approved for usage.

Yes, it is critical that everyone who receives the COVID-19 vaccine receives the entire two-dose course. For the optimum immunity, both Pfizer and AstraZeneca recommend two doses. Pfizer doses are separated by at least 21 days. Doses from AstraZeneca can be spaced 4–12 weeks apart. It’s critical that you acquire the same COVID-19 immunization.

This strategy of giving people numerous doses is referred to as “prime-boosting” by immunologists. Essentially, you stimulate the immune system by teaching it what it’s looking for with the first vaccination. The immune system is then assaulted again once it has had time to respond to the priming. When the immunological response learned the first time is put into practice on the second exposure, it is amplified.

So what happens? When the immune system encounters a vaccination for the first time, it activates two types of white blood cells. The plasma B cells are first, and they are principally responsible for producing antibodies against the infection (or germ that causes disease). Unfortunately, this cell type is only active for a brief period of time. Within a few weeks, your body may be swimming in antibodies. However, without the second dose, antibodies against the virus normally drop rapidly.

Then there are the T cells, which individually identify and eliminate a certain infection. Some of these memory T cells can stay in the body for decades before reaching their destination. This means that immunity to immunizations or diseases can last a lifetime in some cases.

However, you won’t see many of this cell type until you’ve been exposed to the pathogen again, which happens with the booster dosage. If the body is exposed to the same vaccine a second time, it can respond by producing a stronger immune response to combat the infection.

To maximize protection, most (but not all) vaccines involve prime-boosting. Some people may require additional doses. This is due to the fact that immunity might fade over time or, in the case of the flu vaccine, the virus that causes the sickness can evolve, rendering the original vaccine ineffective.

Clinical experiments first revealed the advantages of priming with COVID-19 vaccinations. The immunological responses of persons who received one or two vaccine doses were compared in early investigations of the now licensed COVID-19 vaccines. People had higher levels of antibodies to combat the virus after the second dose, indicating that taking more than one dose would likely boost vaccine effectiveness.

There’s another reason to obtain your second dosage now: new coronavirus strains that are causing concern. These are coronavirus strains with genetic changes that make them more transmissible, less resistant to vaccination protection, more difficult to detect, or cause more severe sickness.

Stay safe and stay healthy!

Check out my related post: How will COVID 19 change travel for us?


Interesting reads:

https://www.nytimes.com/2021/06/24/world/europe/covid-vaccine-mix-and-match-pfizer-moderna.html

https://medicalxpress.com/news/2021-06-covid-vaccine-dose-americans.html

https://www.imc-healthcare.com/all-you-need-to-know-about-singapores-vaccine/

https://jamanetwork.com/journals/jama/fullarticle/2776229

https://www.healthline.com/health/why-two-doses-of-covid-vaccine#dosing-timeframe

https://www.health.gov.au/initiatives-and-programs/covid-19-vaccines/is-it-true/is-it-true-do-people-have-to-receive-two-doses-and-do-they-have-to-be-the-same-type-of-covid-19-vaccine-for-it-to-be-effective

https://www.muhealth.org/our-stories/covid-19-vaccine-what-you-need-know-about-second-dose

https://theconversation.com/covid-19-vaccines-why-its-important-you-get-your-second-dose-161940

https://www.washingtonpost.com/health/interactive/2020/covid-vaccines-what-you-need-to-know/

https://www.webmd.com/vaccines/covid-19-vaccine/news/20210205/why_2_covid_vaccine_doses_are_needed

https://www.immunology.org/coronavirus/connect-coronavirus-public-engagement-resources/why-multiple-doses-covid19-vaccine

https://www.reuters.com/business/healthcare-pharmaceuticals/us-panel-review-heart-inflammation-cases-after-pfizer-moderna-vaccines-2021-06-23/

https://www.cnbc.com/2021/04/05/covid-vaccine-fauci-says-two-shots-of-pfizer-or-moderna-are-better-than-one-.html

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